Relationship between thyroid hormone and sex hormone levels and non-suicidal self-injury in male adolescents with depression

作者：Jiahui Ma, Mingming Zhao, Gengyun Niu, Zhifei Wang, Shan Jiang, Zengxun Liu · 发表于：Frontiers in Psychiatry · 年份：2022 · DOI：10.3389/fpsyt.2022.1071563 · 被引用次数：24 · 研究领域：Suicide and Self-Harm Studies、Traumatic Brain Injury Research、Biochemical and Molecular Research

Objective Non-suicidal self-injury (NSSI) is the intentional and repeated direct injury to one’s bodily tissues or organs without the intent to die, which is not socially sanctioned and does not result in death. This study will be the first to explore the relationship between NSSI behavior and thyroid hormone and sex hormone levels in male adolescents with depression. Methods Among the inpatients in the children’s ward of Shandong Mental Health Center, eighty male patients with first-episode depressive disorder were randomly selected. Forty male adolescent depressed patients with NSSI behaviors were set as the NSSI group, and forty male adolescent depressed patients without NSSI behaviors were set as the No-NSSI group. Their thyroid hormones (free triiodothyronine, free thyroxine, and thyroid stimulating hormone) and sex hormones (estradiol, progesterone, and testosterone) were measured, and the severity of self-injury in the NSSI group was assessed using the Adolescent Self-Injury Questionnaire. The NSSI group was tested again after 6 weeks of sertraline treatment for biological indicators and assessed by the Self-Injury Questionnaire to compare the hormonal differences between the NSSI group and the No-NSSI group and compare the differences of each index before and after treatment in the NSSI group. Results T3/T4 ( p = 0.001) and FT3 ( p = 0.023), TSH levels ( p < 0.001) were lower in the NSSI group than in the No-NSSI group before treatment, and FT4 ( p = 0.036) and...