CEP signaling coordinates plant immunity with nitrogen status

作者：Jakub Rzemieniewski, Henriette Leicher, Hyun Kyung Lee, Caroline Broyart, Shahran Nayem, Christian Wiese, Julian Maroschek, Zeynep Camgöz, Vilde Olsson Lalun, Michael A. Djordjevic, A. Corina Vlot, Ralph Hückelhoven, Julia Santiago, Martin Stegmann · 发表于：bioRxiv (Cold Spring Harbor Laboratory) · 年份：2022 · DOI：10.1101/2022.12.20.521212 · 被引用次数：20 · 研究领域：Legume Nitrogen Fixing Symbiosis、Plant Parasitism and Resistance、Plant-Microbe Interactions and Immunity

Abstract Plant endogenous signaling peptides shape growth, development and adaptations to biotic and abiotic stress. Here, we identified C-TERMINALLY ENCODED PEPTIDEs (CEPs) as novel immune-modulatory peptides (phytocytokines) in Arabidopsis thaliana . Our data reveals that CEPs induce immune outputs and are required to mount resistance against the leaf-infecting bacterial pathogen Pseudomonas syringae pv . tomato . We show that effective immunity requires CEP perception by tissue-specific CEP RECEPTOR 1 (CEPR1) and CEPR2. Moreover, we identified the related RECEPTOR-LIKE KINASE 7 (RLK7) as a novel CEP4-specific CEP receptor contributing to CEP-mediated immunity, suggesting a complex interplay of multiple CEP ligands and receptors in different tissues during biotic stress. CEPs have a known role in the regulation of root growth and systemic nitrogen (N)-demand signaling. We now provide evidence that CEPs and their receptors promote immunity in an N status-dependent manner, suggesting a previously unknown molecular crosstalk between plant nutrition and cell surface immunity. We propose that CEPs and their receptors are central regulators for the adaptation of biotic stress responses to plant-available resources.