Paroxysmal slow wave events are associated with cognitive impairment in patients with obstructive sleep apnea

作者：Mengfan Li, Zhuoran Sun, Hairong Sun, Guochen Zhao, Bing Leng, Tengqun Shen, Song Xue, Huimin Hou, Zhenguang Li, Jinbiao Zhang · 发表于：Alzheimer s Research & Therapy · 年份：2022 · DOI：10.1186/s13195-022-01153-x · 被引用次数：19 · 研究领域：Obstructive Sleep Apnea Research、Sleep and Wakefulness Research、Restless Legs Syndrome Research

Abstract Background Increasing evidence has supported a link between obstructive sleep apnea (OSA) and cognition, and blood-brain barrier (BBB) dysfunction which can be reflected by paroxysmal slow wave events (PSWEs) may be a potential mechanism. The purpose of our study was to investigate the correlation between the PSWEs and cognitive impairment in patients with OSA, with a focus on the possible mechanism. Methods In total, 339 subjects with subjective snoring complaints from the Sleep Medicine Center underwent magnetic resonance imaging and whole-night polysomnography. OSA was defined as apnea-hypopnea index (AHI) ≥ 5 events/h. MCI was defined as the MoCA < 26 and met the criteria: (1) subjective cognitive impairment; (2) objective impairment in one or more cognitive domains; (3) slightly impaired complex instrumental daily abilities, but independent daily living abilities; and (4) no dementia. The PSWEs calculated by self-developed Python scripts were defined for EEG recordings as a median power frequency of < 6 Hz for more than five consecutive seconds. Serum cyclophilin A (CyPA) and matrix metalloproteinase-9 (MMP-9) levels and amyloid-β 42 levels in neuron-derived exosomes were determined. The participants who received continuous positive airway pressure (CPAP) were followed up and their PSWEs were recalculated after 1 year of treatment. Results A total of 339 participants were divided into the OSA+MCI group ( n = 157), OSA-MCI group ( n = 118), and controls (no...