Catalytic asymmetric synthesis of α-tertiary aminoketones from sulfoxonium ylides bearing two aryl groups

作者：Ying Zhou, Xin Yue, Feng Jiang, Jianwei Sun, Wengang Guo · 发表于：Chemical Communications · 年份：2022 · DOI：10.1039/d2cc06147c · 被引用次数：16 · 研究领域：Synthesis and Catalytic Reactions、Catalytic C–H Functionalization Methods、Cyclopropane Reaction Mechanisms

Disclosed herein is an efficient organocatalytic formal N-H insertion reaction of arylamines with α-keto sulfoxonium ylides bearing two aryl groups, delivering a broad range of α-tertiary aminoketones with good to excellent yields and enantioselectivities (up to 90% yield and 94% ee). The utilities of this protocol were also demonstrated by facile preparation of enantioenriched 2-amino-1,2-diarylethanol bearing two different aryl groups, a type of important building block lacking efficient access.