Allyl isothiocyanate dry powder inhaler based on cyclodextrin-metal organic frameworks for pulmonary delivery

作者：Nianxia Sun, Min Zhang, Wen-Tao Zhu, Pingping Song, Tingting Dai, Peng Huang, Zhili Han, Dianlei Wang · 发表于：iScience · 年份：2022 · DOI：10.1016/j.isci.2022.105910 · 被引用次数：22 · 研究领域：Inhalation and Respiratory Drug Delivery、Metal-Organic Frameworks: Synthesis and Applications、Membrane Separation and Gas Transport

In this study, allyl isothiocyanate (AITC) was prepared as the dry powder inhalation by loading cyclodextrin metal-organic framework (CD-MOF) to enhance pulmonary delivery. β-CD-MOF and γ-CD-MOF both could be used to carry AITC with the optimal loading conditions (50˚C, n CD : n AITC = 1:7, 7 h). Compared with β-CD-MOF, γ-CD-MOF had more advantages in AITC loading due to its high drug loading and stable crystal morphology. The particle size and the mass median aerodynamic diameter of γ-CD-MOF-AITC were accorded with the aerodynamic characteristics of lung inhalation. γ-CD-MOF-AITC might be deposited effectively in the deep lung, and the release rate of AITC reached over 90% within 5 min. Meanwhile, it had good pulmonary local tolerance, permeability, and no significant toxicity. Such results indicated that γ-CD-MOF could be used as a dry powder inhaler carrier to deliver safely AITC to lung and increase its pulmonary absorption.