Dextran—An Antigen in Man

作者：Elvin A. Kabat, Deborah T. Berg · 发表于：The Journal of Immunology · 年份：1953 · DOI：10.4049/jimmunol.70.6.514 · 被引用次数：126 · 研究领域：Food Allergy and Anaphylaxis Research

Summary Native and clinical dextrans derived from strains of microorganisms synthesizing products with different ratios of 1:6 to non 1:6 linkages have been found to be antigenic in man. Three weeks after injection of 1 mg of dextran, precipitins and cutaneous sensitivities of the wheal and erythema type develop. The antigenicity of dextran in man, its occurrence in commercial sugar and its elaboration by microorganisms in the gastrointestinal tract appear to provide an explanation for the occurrence of systemic allergic reactions in man on infusion of dextran and for the occurrence of small quantities of antidextran and of cutaneous sensitivity in individuals not previously injected with dextran. The precipitin reaction between dextran and antidextran is of the usual type. Differences in the behavior of various antisera with native and clinical dextran have been interpreted in terms of the structural similarities and differences among the preparations.