Non-invasive high frequency oscillatory ventilation inhibiting respiratory motion in healthy volunteers

作者：Yanshan Zhang, Yanshan Zhang, Xiaojun Li, Yihe Zhang, Yihe Zhang, Yancheng Ye, Yee‐Min Jen, Xin Pan, Pengqing Li, Tianyan Qin, Pengqing Li, Caixia Lv, Ying Qi, Xin Wang, Yuling Yang, Tong Ma · 发表于：Scientific Reports · 年份：2022 · DOI：10.1038/s41598-022-27288-3 · 被引用次数：4 · 研究领域：Advanced Radiotherapy Techniques、Lung Cancer Diagnosis and Treatment、Radiation Therapy and Dosimetry

Abstract Precision radiotherapy needs to manage organ movements to prevent critical organ injury. The purpose of this study is to examine the feasibility of motion control of the lung by suppressing respiratory motion. The non-invasive high frequency oscillatory ventilation (NIHFOV) is a technique commonly used in the protection of lung for patients with acute lung disease. By using a very high respiratory frequency and a low tidal volume, NIHFOV allows gas exchange, maintains a constant mean airway pressure and minimizes the respiratory movements. We tested healthy volunteers NIHFOV to explore the optimal operational parameter setting and the best possible motion suppression achievable. This study was conducted with the approval of Institutional Review Boards of the Wuwei Cancer hospital (approval number: 2021-39) and carried out in accordance with Declaration of Helsinki. The study comprises two parts. Twenty three healthy volunteers participated in the first part of the study. They had 7 sessions of training with the NIHFOV. The duration of uninterrupted, continuous breathing under the NIHFOV and the optimal operational machine settings were defined. Eight healthy volunteers took part in the second part of the study and underwent 4-dimensional CT (4DCT) scanning with and without NIHFOV. Their respiratory waveform under free breathing (FB) and NIHFOV were recorded. The maximum range of motion of the diaphragm from the two scannings was compared, and the variation of bilater...