Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

作者：Yi Xie, Fei Liu, Xiaojing Zhang, Yanyan Jin, Qiuyu Li, Huijun Shen, Haidong Fu, Jianhua Mao · 发表于：Annals of Translational Medicine · 年份：2022 · DOI：10.21037/atm-22-5969 · 被引用次数：55 · 研究领域：Trace Elements in Health、Magnesium in Health and Disease、Heavy Metal Exposure and Toxicity

Background and Objective: Chronic kidney disease (CKD) is an important public health concern. With the decline of renal function, CKD patients gradually progress to end-stage kidney disease and need to undergo dialysis or kidney transplantation to maintain life, bringing a heavy economic burden to the family and society. Therefore, it is necessary to effectively prevent and delay the progression of CKD. Essential trace elements play an indispensable role in CKD, and the objective of this study is to systematically review their benefits in the disease and summarize the risks of their excess. Methods: The keywords "trace elements", "chronic kidney disease", "dialysis", "inflammation", and "fibrosis" and their combinations were used to search for relevant literature published in the PubMed database and Web of Science. We then summarized the role of trace element abnormalities in CKD patients in anemia, oxidative stress, inflammation, and chronic fibrosis, and the risk of their excess. Key Content and Findings: Imbalance of essential trace elements is a common complication of CKD and a risk factor for CKD progression, cardiovascular events, and death. This article reviews the effects of essential trace elements (iron, zinc, selenium, copper, iodine, and manganese) on CKD. We analyze literature and discuss the advantages and disadvantages of various essential trace elements. Conclusions: Research shows CKD patients have an imbalance of essential trace elements, and treatment based...