Cutting Edge: Human Myelomonocytic Cells Express an Inhibitory Receptor for Classical and Nonclassical MHC Class I Molecules

作者：Marco Colonna, Jacqueline Samaridis, Marina Cella, Lena Ångman, Rachel Louise Allen, Christopher A. O’Callaghan, Rod Dunbar, Graham Stuart Ogg, Vincenzo Cerundolo, Antonius Rolink · 发表于：The Journal of Immunology · 年份：1998 · DOI：10.4049/jimmunol.160.7.3096 · 被引用次数：452 · 研究领域：Immune Cell Function and Interaction、Reproductive System and Pregnancy、T-cell and B-cell Immunology

Abstract Leukocyte activation can be negatively regulated by inhibitory receptors specific for MHC class I molecules. While one inhibitory receptor, Ig-like transcript 2 (ILT2), is expressed by all lymphoid and myelomonocytic cell types, other receptors display a more selective tissue distribution. Here we characterize an inhibitory receptor, termed ILT4, which is selectively expressed in monocytes, macrophages, and dendritic cells (DCs), binds classical class I molecules and the nonclassical class I molecules HLA-G, and transduces negative signals that can inhibit early signaling events triggered by stimulatory receptors. ILT4 may control inflammatory responses and cytotoxicity mediated by myelomonocytic cells and may modulate their Ag-presenting functions, focusing immune responses to microbial challenges and avoiding autoreactivity.