Ceftriaxone-resistant, multidrug-resistant Neisseria gonorrhoeae with a novel mosaic penA-237.001 gene, France, June 2022

作者：Béatrice Berçot, François Caméléna, Manel Mérimèche, Susanne Jacobsson, Ghalia Sbaa, Mary Mainardis, Cyrille Valin, Jean‐Michel Molina, Cécile Bébéar, Émilie Chazelle, Florence Lot, Daniel Golparian, Magnus Unemo · 发表于：Eurosurveillance · 年份：2022 · DOI：10.2807/1560-7917.es.2022.27.50.2200899 · 被引用次数：32 · 研究领域：Reproductive tract infections research、Syphilis Diagnosis and Treatment、Bacterial Infections and Vaccines

We report a ceftriaxone-resistant, multidrug-resistant urogenital gonorrhoea case in a heterosexual woman in France, June 2022. The woman was successfully treated with azithromycin 2 g. She had unprotected sex with her regular partner, who developed urethritis following travel to Vietnam and Switzerland. Whole genome sequencing of the gonococcal isolate (F92) identified MLST ST1901, NG-STAR CC-199, and the novel mosaic penA-237.001 , which caused ceftriaxone resistance. penA-237.001 is 98.7% identical to penA-60.001 , reported in various ceftriaxone-resistant strains, including the internationally spreading FC428 clone.