IL-17 and TNF-β: Predictive biomarkers for transition to psychosis in ultra-high risk individuals

作者：Lijun Ouyang, David Li, Zongchang Li, Xiaoqian Ma, Yuan Liu, Lejia Fan, Zihao Yang, Zhenmei Zhang, Chunwang Li, Ying Hé, Xiaogang Chen · 发表于：Frontiers in Psychiatry · 年份：2022 · DOI：10.3389/fpsyt.2022.1072380 · 被引用次数：23 · 研究领域：Tryptophan and brain disorders、Schizophrenia research and treatment、Psoriasis: Treatment and Pathogenesis

Background Dysregulation of immunity, such as levels of inflammatory factors, has been regarded as a sign of schizophrenia. Changes in cytokine levels are not only described in the early onset of disease, but also observed in ultra-high risk (UHR) individuals. This study aimed to investigate the potential of cytokines as biomarkers for psychotic disorders and in individuals at UHR of developing a psychotic disorder in the future. Methods The Luminex liquid chip technology was used to detect the concentrations of Interferon-gamma (INF-γ), Interleukin (IL)-2, Interleukin (IL)-4, Interleukin (IL)-6, Interleukin (IL)-17, Interleukin-1beta (IL-1β), and Tumor Necrosis Factor-beta (TNF-β) in the plasma of all subjects. Meanwhile, the plasma level of Tumor Necrosis Factor-Alpha (TNF-α) was measured with the enzyme-linked immunosorbent assay (ELISA) kits. Then, the levels of these cytokines were compared among patients with Drug-naïve first-episode schizophrenia (FES; n = 40), UHR population (UHR; n = 49), and healthy controls (HCs; n = 30). Baseline cytokine levels were compared among UHR individuals who later transitioned (UHR-T; n = 14), those who did not transition (UHR-NT; n = 35), and HCs ( n = 30). Results Our analysis results showed that IL-1β levels were significantly higher in UHR group than HC group ( p = 0.015). Meanwhile, TNF-α concentration was significantly increased in FES group compared with HC group ( p = 0.027). IL-17 ( p = 0.04) and TNF-β ( p = 0.008) levels were s...