Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ

作者：Hongming Li, Yumei Qiu, Mengdie Xie, Changsheng Ouyang, Xiaoyun Ding, Hao Zhang, Wei Dong, Yinhua Xiong, Xilan Tang · 发表于：Korean Journal of Physiology and Pharmacology · 年份：2022 · DOI：10.4196/kjpp.2023.27.1.75 · 被引用次数：9 · 研究领域：ATP Synthase and ATPases Research、Ubiquitin and proteasome pathways、Cell death mechanisms and regulation

(PLA2G6) and diacylglycerol kinase ζ (DGK-ζ) as targets to further explore the potential mechanism through which momordicine I inhibited ISO-induced cardiomyocyte hypertrophy. Our results demonstrated that momordicine I inhibited ISO-induced upregulations of mRNA levels and protein expressions of PLA2G6 and DGK-ζ. Collectively, momordicine I alleviated ISO-induced cardiomyocyte hypertrophy, which may be related to its inhibition of the expression of glycerophospholipid metabolizing enzymes PLA2G6 and DGK-ζ.