Endoplasmic Reticulum Stress in Osteoarthritis: A Novel Perspective on the Pathogenesis and Treatment

作者：Zeqin Wen, Qi Sun, Yunhan Shan, Wenqing Xie, Yilan Ding, Weiyang Wang, Ruixi Ye, Wenfeng Xiao, Yusheng Li · 发表于：Aging and Disease · 年份：2022 · DOI：10.14336/ad.2022.0725 · 被引用次数：23 · 研究领域：Endoplasmic Reticulum Stress and Disease、Inflammasome and immune disorders、Autoimmune and Inflammatory Disorders Research

Osteoarthritis (OA), the most common degenerative joint disease, causes an enormous socioeconomic burden due to its disabling properties and high prevalence. Increasing evidence suggests that OA is a whole-joint disease involving cartilage degradation, synovitis, meniscal lesions, and subchondral bone remodeling. Endoplasmic reticulum (ER) stress is the accumulation of misfolded/unfolded proteins in the ER. Recent studies have found that ER stress is involved in the OA pathological changes by influencing the physiological function and survival of chondrocytes, fibroblast-like synoviocytes, synovial macrophages, meniscus cells, osteoblasts, osteoclasts, osteocytes, and bone marrow mesenchymal stem cells. Therefore, ER stress is an attractive and promising target for OA. However, although targeting ER stress has been proven to alleviate OA progression in vitro and in vivo , the treatments for OA remain in preclinical stage and require further investigation.