A Review of Electrochemical Electrodes and Readout Interface Designs for Biosensors

作者：Yuan Ma, Yuping Deng, Chao Xie, Bingjing Zhang, Boyu Shen, Milin Zhang, Lan Yin, Xilin Liu, Jan Van der Spiegel · 发表于：IEEE Open Journal of the Solid-State Circuits Society · 年份：2022 · DOI：10.1109/ojsscs.2022.3221924 · 被引用次数：15 · 研究领域：Conducting polymers and applications、Analytical Chemistry and Sensors、Electrochemical Analysis and Applications

Electrochemical detection is widely used in biosensing fields, such as medical diagnosis and health monitoring due to its real-time response and high accuracy. Both passive and active electrodes and the corresponding readout circuits have been continuously improved over the past decades. This article summarizes the redox reaction method, state-of-the-art electrode materials, and readout circuits based on the passive three-electrode. The redox-current-based readout circuits are widely used and developed toward multichannel high precision and low power consumption. In terms of active electrodes, this article reviews the development of field-effect transistors (FETs)-based electrochemical detection and readout circuits. In the past decade, the development of organic electrochemical transistors (OECTs) has also enabled more precise electrochemical detection.