Copper-catalyzed enantioselective fluoroalkenylation of cyclic imino esters

作者：Zhiwei Chen, Xiang Huang, Jian Liao, Min Wang · 发表于：Organic Chemistry Frontiers · 年份：2022 · DOI：10.1039/d2qo01141g · 被引用次数：10 · 研究领域：Fluorine in Organic Chemistry、Catalytic C–H Functionalization Methods、Cyclopropane Reaction Mechanisms

A copper-catalyzed enantioselective fluoroalkenylation of cyclic imino esters was developed. Using this protocol, tetrasubstituted monofluoroalkenes bearing a quaternary center were afforded in good yields with high E / Z -selectivities and excellent enantioselectivities.