Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues

作者：Likun Ai, Shiqi Fu, Yong Li, Mei Zuo, Wen Huang, Jian Huang, Zhichao Jin, Chen Yang · 发表于：Frontiers in Plant Science · 年份：2022 · DOI：10.3389/fpls.2022.1102411 · 被引用次数：37 · 研究领域：Fungal Plant Pathogen Control、Microbial Natural Products and Biosynthesis、Phytochemical compounds biological activities

Botanical pesticides are one of the sources of third-generation pesticides, which have received much attention at home and abroad in recent years due to their degradable and pollution-free advantages in nature. This article explored a concise approach toward synthesizing a series of novel L-pyroglutamic acid analogues from L-hydroxyproline. Furthermore, bioassay studies of these sulfonyl ester derivatives against Pyricularia oryzae , Fusarium graminearum , Alternaria brassicae , Valsa mali , and Alternaria alternariae showed moderate antifungal activity. For instance, C08a and C08l provide potential lead agents for controlling Fusarium graminearum because of their inhibitory activity.