TREM2 dependent and independent functions of microglia in Alzheimer’s disease

作者：Jinchao Hou, Yun Chen, Gary E. Grajales‐Reyes, Marco Colonna · 发表于：Molecular Neurodegeneration · 年份：2022 · DOI：10.1186/s13024-022-00588-y · 被引用次数：198 · 研究领域：Neuroinflammation and Neurodegeneration Mechanisms、Inflammation biomarkers and pathways、Neurological Disease Mechanisms and Treatments

Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the genetic and functional discoveries that have advanced our understanding of microglia reactivity to AD pathology. Given the heightened AD risk posed by rare variants of the microglial triggering receptor expressed on myeloid cells 2 (TREM2), we will focus on the studies addressing the impact of this receptor on microglia responses to amyloid plaques, tauopathy and demyelination pathologies in mouse and human. Finally, we will discuss the implications of recent discoveries on microglia and TREM2 biology on potential therapeutic strategies for AD.