Glycyrrhizic acid alters the hyperoxidative stress-induced differentiation commitment of MSCs by activating the Wnt/β-catenin pathway to prevent SONFH

作者：Huihui Xu, Liang Fang, Qinghe Zeng, Jiali Chen, Houfu Ling, Hanting Xia, Qinwen Ge, Congzi Wu, Kaiao Zou, Xu Wang, Pinger Wang, Wenhua Yuan, Rui Dong, Songfeng Hu, Luwei Xiao, Bangjian He, Peijian Tong, Hongting Jin · 发表于：Food & Function · 年份：2022 · DOI：10.1039/d2fo02337g · 被引用次数：31 · 研究领域：Bone and Joint Diseases、Pharmacological Effects of Natural Compounds、Autoimmune and Inflammatory Disorders Research

, GA reduced dexamethasone (Dex)-induced excessive NOX4 and OS levels by activating the Wnt/β-catenin pathway, thereby promoting the osteogenic differentiation of mesenchymal stem cells (MSCs) and inhibiting lipogenic differentiation. In addition, GA regulated the expression levels of the key transcription factors downstream of this pathway, Runx2 and PPARγ, thus maintaining osteolipogenic homeostasis. In summary, we demonstrated for the first time that GA modulates the osteolipogenic differentiation commitment of MSCs induced by excessive OS through activating the Wnt/β-catenin pathway, thereby ameliorating SONFH.