Association of Psychosocial Stress With Risk of Acute Stroke

作者：Catriona Reddin, Robert Murphy, Graeme J. Hankey, Conor Judge, Denis Xavier, Annika Rosengren, John Ferguson, Alberto Alvarez‐Iglesias, Shahram Oveisgharan, Helle K. Iversen, Fernando Laņas, Fawaz Alhussein, Anna Członkowska, Aytekin Oğuz, Clodagh McDermott, Nana Pogosova, Germán Málaga, Peter Langhorne, Xingyu Wang, Mohammad Wasay, Salim Yusuf, Martin O’Donnell, INTERSTROKE investigators, Sumathy Rangaran, Rao Ps, Xiaohe Zhang, Shofiqul Islam, Conrad Kabali, Amparo Cassanova, Siu Lim Chin, Jane DeJesus, Mahshid Dehghan, Steven Agapay, Rafael Díaz, George Varigos, Álvaro Avezum, Lisheng Liu, Hongye Zhang, Patricio López‐Jaramillo, Zvonko Rumboldt, Ernesto Peñaherrera, Hans-Christopher Diener, Prem Pais, Osamah Albaker, Khalid Yusoff, Albertino Damasceno, Okechukwu S. Ogah, Romaina Iqbal, Antonio Dans, Danuta Ryglewicz, Linda de Villiers, Ahmed ElSayed, Yongchai Nilanont, Samart Nidhinandana, Charles Mondo, Alfzalhussein Yusufali · 发表于：JAMA Network Open · 年份：2022 · DOI：10.1001/jamanetworkopen.2022.44836 · 被引用次数：60 · 研究领域：Stroke Rehabilitation and Recovery、Acute Ischemic Stroke Management、Cardiac Health and Mental Health

Importance: Psychosocial stress is considered a modifiable risk factor for stroke. Given the prevalence of chronic and acute exposure to stress, it represents a potentially attractive target for population-health interventions. Objectives: To determine the association of psychosocial stress with the risk of acute stroke and explore factors that might modify the association of stress with risk of acute stroke in a large international population. Design, Setting, and Participants: INTERSTROKE is an international retrospective case-control study of risk factors for first acute stroke in 32 countries in Asia, North and South America, Europe, Australia, the Middle East, and Africa. A total of 13 462 patients with stroke and 13 488 matched controls were recruited between January 11, 2007, and August 8, 2015. The present analyses were performed from June 1 to 30, 2021, and included 13 350 cases and 13 462 controls with available data on psychosocial stress. Exposures: Psychosocial stress and occurrence of stressful life events within the preceding year were measured using a standardized questionnaire of self-reported stress at home and work. Main Outcomes and Measures: The association of stress with acute stroke and its subtypes was examined using multivariable conditional logistic regression and factors that might modify the association, particularly self-reported locus of control. Results: Among 26 812 participants included in the analysis, the mean (SD) age of cases was 62.2 (13....