Phosphine-catalyzed activation of cyclopropenones: a versatile C 3 synthon for (3+2) annulations with unsaturated electrophiles

作者：Xin He, Pengchen Ma, Yuhai Tang, Jing Li, Shenyu Shen, Martin J. Lear, K. N. Houk, Silong Xu · 发表于：Chemical Science · 年份：2022 · DOI：10.1039/d2sc04092a · 被引用次数：43 · 研究领域：Cyclopropane Reaction Mechanisms、Synthetic Organic Chemistry Methods、Catalytic C–H Functionalization Methods

A phosphine-catalyzed (3 + 2) annulation of cyclopropenones with a wide variety of electrophilic π systems has been developed, in which an α-ketenyl phosphorous ylide is validated as the key intermediate used as a versatile C 3 synthon.