Synthesis of Chiral Spiro[oxindole-3,2′-pyrrolidine] Derivatives Integrated with Spiro Indane-1,3-dione and Trifluoromethyl Group Pharmacophores via Organocatalyzed Asymmetric [3+2] Annulation

作者：Zhenghong Zhou, Li Fei, Zhuo Li, Youming Wang · 发表于：Synthesis · 年份：2022 · DOI：10.1055/a-1993-4132 · 被引用次数：9 · 研究领域：Fluorine in Organic Chemistry、Asymmetric Synthesis and Catalysis、Oxidative Organic Chemistry Reactions

Abstract A mild and efficient organocatalyzed [3+2] cycloaddition of isatin-derived ketimines and 2-ylideneindane-1,3-diones has been realized. The resulting spiro[oxindole-3,2′-pyrrolidine]s bearing both a spiro indane-1,3-dione motif and a trifluoromethyl group were obtained in high yields with good diastereo- and enantioselectivities.