Age-specific reference values for low psoas muscle index at the L3 vertebra level in healthy populations: A multicenter study

作者：Ming Kong, Ning Lin, Lili Wang, Nan Geng, Manman Xu, Shanshan Li, Wenyan Song, Ying Zhou, Yuetong Piao, Zuoqing Han, Rong Guo, Chao Yang, Nan Luo, Zhong Wang, Quanxiao Xu, Daimeng Shi, Wanchun Qiu, Junfeng Li, Eddie C. Cheung, Lei Ma, Yu Chen, Zhongping Duan · 发表于：Frontiers in Nutrition · 年份：2022 · DOI：10.3389/fnut.2022.1033831 · 被引用次数：19 · 研究领域：Nutrition and Health in Aging、Bone health and osteoporosis research、Body Composition Measurement Techniques

Background and aims The progressive and generalized loss of skeletal muscle mass, strength and physical function is defined as sarcopenia. Sarcopenia is closely related to the prognosis of patients. Accurate diagnosis and adequate management of sarcopenia are crucial. The psoas muscle mass index taken at the third lumbar vertebra (L3-PMI, cm 2 /m 2 ) is one of the established methods for evaluating skeletal muscle mass. However, the cutoff values of L3-PMI for diagnosis of sarcopenia are not yet to be clarified in Asian populations. We attempted to establish reference values for low L3-PMI that would be suitable for defining sarcopenia in the Northern Chinese population. Methods This was a retrospective, multicenter cross-sectional study. A search of abdominal CT imaging reports was conducted in four representative cities in northern China. Transverse CT images were measured using the analysis software Slice-O-Matic. Low psoas muscle index was defined as the 5th percentile or mean-2SD of the study group. Results 1,787 healthy individuals in the study were grouped by age. The sex and number of people in each group were similar. L3-PMI had a negative linear correlation with age, and a strong correlation with the skeletal muscle index taken at the third lumbar vertebrae (L3-SMI, cm 2 /m 2 ). The L3-PMI reference values in males were 5.41 cm 2 /m 2 for 20–29 years, 4.71 cm 2 /m 2 for 30–39 years, 4.65 cm 2 /m 2 for 40–49 years, 4.10 cm 2 /m 2 for 50–59 years and 3.68 cm 2 /m 2 fo...