Dietary Lactobacillus fermentum and Lactobacillus paracasei improve the intestinal health of broilers challenged with coccidia and Clostridium perfringens

作者：Peng Li, Liyun Zheng, QI Ya, Zhipeng Liu, Encun Du, Jintao Wei, Zhengfan Zhang, Shuangshuang Guo, Binying Ding · 发表于：Frontiers in Veterinary Science · 年份：2022 · DOI：10.3389/fvets.2022.1025677 · 被引用次数：21 · 研究领域：Animal Nutrition and Physiology、Probiotics and Fermented Foods、Pharmacological Effects of Natural Compounds

Necrotic enteritis (NE) is a great threat to the intestinal health of broilers, resulting in decreased growth performance and significant economic losses. Lactobacillus fermentum ( LF ) and Lactobacillus paracasei ( LP ) exert beneficial effects on intestinal health. The aim of the present study was to investigate the effects of dietary LF and LP on the intestinal health and growth performance of broilers challenged with coccidia and Clostridium perfringens (CCP). The animal trial was carried out using 336 broilers (Ross 308) for 35 days with a completely randomized design. The broilers were divided into 4 groups based on treatment as follows: the control (CTR) group was fed the basal diet and without CCP challenge and the CCP group was fed the basal diet and with CCP challenge. The broilers in the CCP+ LF and CCP+ LP groups were challenged by CCP, and meanwhile, LF (1 × 10 9 CFU/g) and LP (1 × 10 9 CFU/g) were supplemented into the basal diets, respectively. The results showed that the growth performance and the intestinal morphology were negatively affected by the CCP challenge. In addition, the number of coccidia in the intestinal digesta and the relative abundance of Escherichia coli in the cecal digesta were increased. Besides, the mRNA level of IgA in the jejunum was downregulated, and the transcript level of IL-8 was upregulated by the CCP challenge. Dietary LF and LP failed to improve the growth performance of broilers with the CCP challenge. However, they were benefi...