BrainStat: A toolbox for brain-wide statistics and multimodal feature associations

作者：Sara Larivière, Şeyma Bayrak, Reinder Vos de Wael, Oualid Benkarim, Peer Herholz, Raúl Rodríguez‐Cruces, Casey Paquola, Seok‐Jun Hong, Bratislav Mišić, Alan C. Evans, Sofie L. Valk, Boris C. Bernhardt · 发表于：NeuroImage · 年份：2022 · DOI：10.1016/j.neuroimage.2022.119807 · 被引用次数：132 · 研究领域：Functional Brain Connectivity Studies、Advanced Neuroimaging Techniques and Applications、Neural dynamics and brain function

Analysis and interpretation of neuroimaging datasets has become a multidisciplinary endeavor, relying not only on statistical methods, but increasingly on associations with respect to other brain-derived features such as gene expression, histological data, and functional as well as cognitive architectures. Here, we introduce BrainStat - a toolbox for (i) univariate and multivariate linear models in volumetric and surface-based brain imaging datasets, and (ii) multidomain feature association of results with respect to spatial maps of post-mortem gene expression and histology, task-based fMRI meta-analysis, as well as resting-state fMRI motifs across several common surface templates. The combination of statistics and feature associations into a turnkey toolbox streamlines analytical processes and accelerates cross-modal research. The toolbox is implemented in both Python and MATLAB, two widely used programming languages in the neuroimaging and neuroinformatics communities. BrainStat is openly available and complemented by an expandable documentation.