Dietary inflammatory index, and depression and mortality risk associations in U.S. adults, with a special focus on cancer survivors

作者：Yuzheng Zhang, Yanhua Wu, Yangyu Zhang, Donghui Cao, Hua He, Xueyuan Cao, Yuehui Wang, Zhifang Jia, Jing Jiang · 发表于：Frontiers in Nutrition · 年份：2022 · DOI：10.3389/fnut.2022.1034323 · 被引用次数：23 · 研究领域：Nutritional Studies and Diet、Inflammatory Biomarkers in Disease Prognosis、Tryptophan and brain disorders

Introduction A higher risk for depression and mortality is associated with the inflammatory potential of diet measured through the Dietary Inflammatory Index (DII). The roles of DII in the risk of depression and death in cancer survivors were unclear. We aimed to examine the association between energy-adjusted DII (E-DII) score and risk of depression, and mortality using data from the 2007–2018 National Health and Nutrition Examination Survey (NHANES), with a special focus on cancer survivors. Methods The 24-h dietary recall interview was used as a basis to calculate the E-DII score and the Patient Health Questionnaire-9 (PHQ-9) was used to measure the depressive outcomes. Logistic regression analyses were performed to determine the association between quartiles of E-DII score and depression. Cox proportional hazard regression and competing risk analyses were used to estimate the risks of quartiles of E-DII score or depression on mortality. Results A total of 27,447 participants were included; including 24,694 subjects without cancer and 2,753 cancer survivors. The E-DII score and depression were not distributed differently between the two groups. However, the E-DII scores were positively associated with within each group’s depression (all P trend < 0.001) and participants with higher E-DII scores had a higher risk of depression (subjects without cancer: OR Q4 vs Q1 : 2.17, 95% CI: 1.75–2.70; cancer survivors: OR Q4 vsQ1 : 1.78, 95% CI: 1.09–2.92). The median follow-up...