Characterizations of the Gut Bacteriome, Mycobiome, and Virome in Patients with Osteoarthritis

作者：Changming Chen, Yue Zhang, Xueming Yao, Shenghui Li, Guangyang Wang, Ying Huang, Yutao Yang, Aiqin Zhang, Can Liu, Dan Zhu, Hufan Li, Qiulong Yan, Wukai Ma · 发表于：Microbiology Spectrum · 年份：2022 · DOI：10.1128/spectrum.01711-22 · 被引用次数：53 · 研究领域：Gut microbiota and health、Clostridium difficile and Clostridium perfringens research、Mycobacterium research and diagnosis

The gut microbiome of OA patients was completely altered compared to that in healthy individuals, including 279 differentially abundant bacterial species, 10 fungal species and 627 viral operational taxonomic units (vOTUs). Functional analysis of the gut bacteriome and virome also revealed their functional signatures in relation to OA. We found that OA-associated gut bacterial and viral signatures were tightly interconnected, indicating that they may affect the disease together. The OA patients can be discriminated effectively from healthy controls using the multikingdom signatures, suggesting the potential of gut microbiota for the prediction of OA and related diseases.