New developments in non-exosomal and exosomal ncRNAs in coronary artery disease

作者：Jingru Li, Xinyu Wu, Haocheng Ma, Guihu Sun, Peng Ding, Lu Si, Lijiao Zhang, Ping Yang, Yunzhu Peng, Jingyun Fu, Luqiao Wang · 发表于：Epigenomics · 年份：2022 · DOI：10.2217/epi-2022-0201 · 被引用次数：10 · 研究领域：Circular RNAs in diseases、Extracellular vesicles in disease、MicroRNA in disease regulation

Aim & methods: Non-exosomal and exosomal ncRNAs have been reported to be involved in the regulation of coronary artery disease (CAD). Therefore, to explore the biological effects of non-exosomal/exosomal ncRNAs in CAD, the authors searched for studies published in the last 3 years on these ncRNAs in CAD and summarized their functions and mechanisms. Results: The authors summarized 120 non-exosomal ncRNAs capable of regulating CAD progression. In clinical studies, 47 non-exosomal and nine exosomal ncRNAs were able to serve as biomarkers for the diagnosis of CAD. Conclusion: Non-exosomal/exosomal ncRNAs are not only able to serve as biomarkers for CAD diagnosis but can also regulate CAD progression through ceRNA mechanisms and are a potential target for early clinical intervention in CAD.