Immune mechanism of gut microbiota and its metabolites in the occurrence and development of cardiovascular diseases

作者：Jing Lu, Xiao Jin, Shengjie Yang, Yujuan Li, Xinyue Wang, Min Wu · 发表于：Frontiers in Microbiology · 年份：2022 · DOI：10.3389/fmicb.2022.1034537 · 被引用次数：31 · 研究领域：Gut microbiota and health、Clostridium difficile and Clostridium perfringens research、Tryptophan and brain disorders

The risk of cardiovascular disease (CVD) is associated with unusual changes in the human gut microbiota, most commonly coronary atherosclerotic heart disease, hypertension, and heart failure. Immune mechanisms maintain a dynamic balance between the gut microbiota and the host immune system. When one side changes and the balance is disrupted, different degrees of damage are inflicted on the host and a diseased state gradually develops over time. This review summarizes the immune mechanism of the gut microbiota and its metabolites in the occurrence of common CVDs, discusses the relationship between gut-heart axis dysfunction and the progression of CVD, and lists the currently effective methods of regulating the gut microbiota for the treatment of CVDs.