A dual aperture (mesoporous and macroporous) system loaded with cell-free fat extract to optimize bone regeneration microenvironment

作者：Enhui Qiu, Yan Gong, Jieran Yao, Jinqing Lai, Zhihua Liu, Da‐Peng Yang, Li Shen, Xiangrong Chen · 发表于：Journal of Materials Chemistry B · 年份：2022 · DOI：10.1039/d2tb01980a · 被引用次数：9 · 研究领域：Mesenchymal stem cell research、Bone Tissue Engineering Materials、Bone and Dental Protein Studies

-glycolic acid) (PLGA) (Ceffe-MSN@PLGA) to mimic the developmental spatial structure, the microenvironment of bone regeneration and integration during injured bone regeneration. In this system, a macroporous scaffold (pore size 200-250 μm) of PLGA is combined with mesoporous MSN (pore size 2-50 nm), aiming at realizing the slow release of Ceffe. Besides, PLGA and MSN are used to recruit the temporary support of cells that are able to degrade simultaneously with bone regeneration and provide space for bone tissue regeneration. And the Ceffe isolated from fresh human adipose tissue has a therapeutic effect in regulating the important functions of early inflammatory cell transformation, neovascularization and eventual osteogenic differentiation. Our results suggest that the mesoporous and macroporous Ceffe-MSN@PLGA system represents a promising strategy to better fit the regeneration of injured bone tissue.