In vivo growth of subclones derived from Lewis lung carcinoma is determined by the tumor microenvironment.

作者：Benling Xu, Xiaoming Wang, Guangyu Chen, Peng Yuan, Lu Han, Qin Peng, Tie-Peng Li, Hongqin You, Chengjuan Zhang, Xiaomin Fu, Long Yuan, Zi-Bing Wang, Quanli Gao · 发表于：PubMed · 年份：2022 · 被引用次数：12 · 研究领域：Cancer Cells and Metastasis、Cancer Genomics and Diagnostics、Single-cell and spatial transcriptomics

T cells and NK cells in the tumor tissue of tumor-bearing mice inoculated with SCC2 were significantly higher, whereas those of myeloid cells were significantly lower, than those in the SCC1 and LLC1 groups. Our results suggest that the in vivo growth of two subclones derived from LLC1 was determined by the tumor microenvironment rather than their intrinsic proliferative cell characteristics.