Altered functional connectivity of the right caudate nucleus in chronic migraine: a resting-state fMRI study

作者：Ziyu Yuan, Wei Wang, Xueyan Zhang, Xiaoyan Bai, Hefei Tang, Yanliang Mei, Peng Zhang, Dong Qiu, Xue Zhang, Yaqing Zhang, Xueying Yu, Binbin Sui, Yonggang Wang · 发表于：The Journal of Headache and Pain · 年份：2022 · DOI：10.1186/s10194-022-01506-9 · 被引用次数：39 · 研究领域：Migraine and Headache Studies、Functional Brain Connectivity Studies、Traumatic Brain Injury Research

BACKGROUND: The definitive pathogenic mechanisms underlying chronic migraine (CM) remain unclear. Mounting evidence from functional and structural magnetic resonance imaging (MRI) studies suggests that the caudate nucleus (CN) plays a role in the cognitive, sensory, and emotional integration of pain information in patients with migraine. However, evidence concerning the role played by CN in CM patients is limited. Here, we used the CN as the seed to explore patterns of functional connectivity (FC) among healthy controls (HCs), patients with episodic migraine (EM), and patients with CM. METHODS: We included 25 HCs, 23 EM patients, and 46 CM patients in this study. All participants underwent resting-state functional MRI scans on a GE 3.0T MRI system. We performed seed-based FC analyses among the three groups using the bilateral CNs as seeds. We also compared the subgroups of CM (with and without medication overuse headache, males and females) and performed Pearson's correlation analyses between FC values and the clinical features of CM patients. RESULTS: FC values between the right CN and five clusters (mainly involved in emotion, cognition, and sensory-related brain regions) were higher in CM patients than in HCs. Compared to EM patients, enhanced FC values between the bilateral precuneus, left anterior cingulate gyrus, right middle cingulate cortex, right lingual gyrus, and right CN were shown in the CM patients. There were no significant differences between CM patients with ...