The IRE1α-XBP1 Signaling Axis Promotes Glycolytic Reprogramming in Response to Inflammatory Stimuli

作者：Bevin C. English, Hannah P. Savage, Scott P. Mahan, Vladimir E. Diaz-Ochoa, Briana M. Young, Basel H. Abuaita, Gautam Sule, Jason S. Knight, Mary O’Riordan, Andreas J. Bäumler, Renée M. Tsolis · 发表于：mBio · 年份：2022 · DOI：10.1128/mbio.03068-22 · 被引用次数：14 · 研究领域：Endoplasmic Reticulum Stress and Disease、Autophagy in Disease and Therapy、Immune Cell Function and Interaction

The immune system must be able to tailor its response to different types of pathogens in order to eliminate them and protect the host. When confronted with bacterial pathogens, macrophages, frontline defenders in the immune system, switch to a glycolysis-driven metabolism to carry out their antibacterial functions. Here, we show that IRE1α, a sensor of ER stress, and its downstream transcription factor XBP1 support glycolysis in macrophages during infection with Brucella abortus or challenge with Salmonella LPS. Interestingly, these stimuli activate IRE1α by independent mechanisms. While the IRE1α-XBP1 signaling axis promotes the glycolytic switch, activation of this pathway is not sufficient to increase glycolysis in macrophages. This study furthers our understanding of the pathways that drive macrophage immunometabolism and highlights a new role for IRE1α and XBP1 in innate immunity.