Coexistence of Multidrug Resistance and Virulence in a Single Conjugative Plasmid from a Hypervirulent Klebsiella pneumoniae Isolate of Sequence Type 25

作者：Peiwen Xia, Yi Miao, Yaling Yuan, Jinzhu Huang, Bingxue Yang, Jiajia Liao, Zijun Dang, Shengli Luo, Yun Xia · 发表于：mSphere · 年份：2022 · DOI：10.1128/msphere.00477-22 · 被引用次数：21 · 研究领域：Antibiotic Resistance in Bacteria、Antibiotics Pharmacokinetics and Efficacy、Enterobacteriaceae and Cronobacter Research

The increased reporting of carbapenem-resistant hypervirulent K. pneumoniae is considered a worrisome concern to human health care and has restricted the choice of effective antibiotics for clinical treatment. Moreover, virulence plasmids with complete conjugation modules have been identified, which evolved via homologous recombination.