Metabolic Promiscuity of an Orphan Small Alarmone Hydrolase Facilitates Bacterial Environmental Adaptation

作者：Danny K. Fung, Kaihong Bai, Jin Yang, Xiaoli Xu, David Stevenson, Daniel Amador‐Noguez, Laixin Luo, Jue D. Wang · 发表于：mBio · 年份：2022 · DOI：10.1128/mbio.02422-22 · 被引用次数：12 · 研究领域：Polyamine Metabolism and Applications、Porphyrin Metabolism and Disorders、Amino Acid Enzymes and Metabolism

displayed increased alarmone levels during starvation, loss of interspecies competitive fitness, growth defects, and strong reduction in NADH. Our findings reveal the importance of NADPH hydrolysis by a bacterial SAH. Our work is also the first report of significant physiological roles of bacterial SAHs beyond functioning as antitoxins and suggests that SAHs have far broader physiological roles and share similar functions across domains of life.