Recent Nanotechnologies to Overcome the Bacterial Biofilm Matrix Barriers

作者：Xinyi Lv, Leichen Wang, Anqing Mei, Yanchao Xu, Xiaohong Ruan, Wenjun Wang, Jinjun Shao, Dongliang Yang, Xiaochen Dong · 发表于：Small · 年份：2022 · DOI：10.1002/smll.202206220 · 被引用次数：170 · 研究领域：Bacterial biofilms and quorum sensing、Nanoplatforms for cancer theranostics、Inhalation and Respiratory Drug Delivery

Bacterial biofilm-related infectious diseases severely influence human health. Under typical situations, pathogens can colonize inert or biological surfaces and form biofilms. Biofilms are functional aggregates that coat bacteria with extracellular polymeric substances (EPS). The main reason for the failure of biofilm infection treatment is the low permeability and enrichment of therapeutic agents within the biofilm, which results from the particular features of biofilm matrix barriers such as negatively charged biofilm components and highly viscous compact EPS structures. Hence, developing novel therapeutic strategies with enhanced biofilm penetrability is crucial. Herein, the current progress of nanotechnology methods to improve therapeutic agents' penetrability against biofilm matrix, such as regulating material morphology and surface properties, utilizing the physical penetration of nano/micromotors or microneedle patches, and equipping nanoparticles with EPS degradation enzymes or signal molecules, is first summarized. Finally, the challenges, perspectives, and future implementations of engineered delivery systems to manage biofilm infections are presented in detail.