Dense Conductive Metal–Organic Frameworks as Robust Electrocatalysts for Biosensing

作者：Kai Niu, Pengcheng Sun, Jiping Chen, Xianbo Lu · 发表于：Analytical Chemistry · 年份：2022 · DOI：10.1021/acs.analchem.2c03766 · 被引用次数：42 · 研究领域：Metal-Organic Frameworks: Synthesis and Applications、Conducting polymers and applications、Electrochemical Analysis and Applications

Due to the fascinating properties such as high porosity, large surface areas, and tunable chemical components, metal–organic frameworks (MOFs) have emerged in many fields including catalysis, energy storage, and gas separation. However, the intrinsic electrical insulation of MOFs severely restricts their application in electrochemistry. Here, we synthesize a series of 2D conductive MOFs (cMOFs) through tuning the structure with atomic precision using simple hydrothermal methods. Various electroactive probes are used to reveal the structure–property relationships in 2D cMOFs. Then, we demonstrate the first exploration and implementation of 2D cMOFs toward the construction of electrochemical biosensors. In particular, the biosensor based on Cu 3 (tetrahydroxy-1,4-quinone) 2 [Cu 3 (THQ) 2 ] displays a remarkably improved electrocatalytic performance at a much lower potential. The mechanism study reveals the essential role of charge-transfer interactions between the dense catalytic sites of Cu 3 (THQ) 2 and analytes. Furthermore, the Cu 3 (THQ) 2 -based biosensor demonstrates robust anti-interference capability, good stability, fast response speed, and an ultralow detection limit for paraoxon. These promising results indicate the great potential of cMOFs in biomedical, food safety, and environmental sensing applications.