4-Octyl itaconate regulates immune balance by activating Nrf2 and negatively regulating PD-L1 in a mouse model of sepsis

作者：Peng Zhang, Yaxin Wang, Wengchang Yang, Yuping Yin, Chengguo Li, Xianxiong Ma, Liang Shi, Ruidong Li, Kaixiong Tao · 发表于：International Journal of Biological Sciences · 年份：2022 · DOI：10.7150/ijbs.74456 · 被引用次数：46 · 研究领域：Genomics, phytochemicals, and oxidative stress、Macrophage Migration Inhibitory Factor、Vitamin C and Antioxidants Research

Introduction: Sepsis is a major global health challenge with high mortality rates and no effective treatment. Recent studies have suggested that sepsis may be associated with immune system dysfunction. Itaconate may exert anti-inflammatory effects via Nrf2 signaling. Although Nrf2 regulates oxidative/exogenous stress responses and inhibits inflammatory responses, the mechanism via which Nrf2 regulates immune checkpoints in sepsis remains unclear.