Are chemical compounds in medical mushrooms potent against colorectal cancer carcinogenesis and antimicrobial growth?

作者：John M. Macharia, Lu Zhang, Ruth W. Mwangi, Nóra Rozmann, Zsolt Káposztás, Tímea Varjas, M. Sugár, Huda Alfatafta, Márton Pintér, Bence L. Raposa · 发表于：Cancer Cell International · 年份：2022 · DOI：10.1186/s12935-022-02798-2 · 被引用次数：20 · 研究领域：Fungal Biology and Applications、Phytochemistry and Bioactivity Studies、Herbal Medicine Research Studies

After cardiovascular diseases, cancer is the second main cause of death globally. Mushrooms have been demonstrated to contain amalgamation with properties capable of inhibiting carcinogenesis and microbial growth, principally secondary metabolites such as quinolones, steroids, terpenes, anthraquinones, and benzoic acid derivatives among others. This study aimed to substantiate their potency concerning colon cancer carcinogenesis and antimicrobial growth. A systematic search of important literature was performed considering all the articles published until April 2022. Screening was performed by searching the BMC Springer, Elsevier, Embase, Web of Science, Ovid, and MEDLINE databases. In addition, Google Scholar was used to supplement information. Titles and abstracts that matched the established criteria were selected for full-text article scrutiny and subsequently used in the updated present review. Bioactive compounds present in medicinal mushrooms such as ascorbic acid, organic acids, flavonoids, polysaccharides, glycosides, phenols, linoleic acid, grifolin, and tocopherols among other compounds play a key role in suppressing the proliferation of cancerous cells and selectively act as antibacterial and antifungal agents. These metabolites actively scavenge oxygen free radicals, hydroxyl radicals, and nitrite radicals that would otherwise increase the risks of the growth and development of cancerous cells. Mushrooms' bioactive compounds and metabolites actively inhibit nucle...