The design and implementation of natural population cohort study Biobank: A multiple-center project cooperation with medical consortia in Southwest China

作者：Ping Fan, Shu Zhang, Weiya Wang, Zongze Yang, Weiwei Tan, Shujun Li, Chenxing Zhu, Dan Hu, Xinran Zhou, Zixuan Tian, Yaxi Wang, Fang Liu, Wei Huang, Lei Chen · 发表于：Frontiers in Public Health · 年份：2022 · DOI：10.3389/fpubh.2022.996169 · 被引用次数：14 · 研究领域：Health, Environment, Cognitive Aging、Ethics in Clinical Research、Metabolomics and Mass Spectrometry Studies

Objective: The West China Hospital of Sichuan University collaborated with regional medical consortia in Sichuan Province to launch a natural population cohort study (NPCS) to investigate the health status of residents and collect public health data in southwest China. Methods: Up to 80,000 participants will be enrolled by the NPCS from 11 regional medical consortia over five years. Individuals are invited to visit one of 11 participating medical consortia to fill out questionnaires, receive a free health exam, and donate biospecimens upon enrolment. All participating medical facilities adhered to standard operating procedures for collecting and processing biospecimens to ensure uniformity (serum, lithium heparinized plasma, ethylene diamine tetraacetie acid plasma, and buffy coat). The Electronic Data Capture System, Picture Archiving and Communication System, Laboratory Information Management System, Biospecimen Quality Control System, Biobank Information Management System, and will be used to sort and classify clinical indices, imaging data, laboratory parameters, pre-analytical variables, and biospecimen information, respectively. All quality assurance and quality control procedures in the NPCS biobank adhered to the "DAIDS Guidelines for Good Clinical Laboratory Practice Standards". This project will integrate high-dimensional multi-omics data, laboratory data, clinical data, questionnaire data, and environmental risk factors. Results: An estimated 2,240,000 aliquots of ...