Smoking Behaviors and Prognosis in Patients With Non–Muscle-Invasive Bladder Cancer in the Be-Well Study

作者：Marilyn L. Kwan, Reina Haque, Kelly C. Young‐Wolff, Valerie S. Lee, Janise M. Roh, Isaac Joshua Ergas, Zinian Wang, Kimberly L. Cannavale, Christine B. Ambrosone, Ronald K. Loo, David S. Aaronson, Charles P. Quesenberry, Lawrence H. Kushi, Li Tang · 发表于：JAMA Network Open · 年份：2022 · DOI：10.1001/jamanetworkopen.2022.44430 · 被引用次数：31 · 研究领域：Bladder and Urothelial Cancer Treatments、Smoking Behavior and Cessation、Urinary and Genital Oncology Studies

Importance: Tobacco smoking is an established risk factor associated with bladder cancer, yet its impact on bladder cancer prognosis is unclear. Objective: To examine associations of use of tobacco (cigarettes, pipes, and cigars), e-cigarettes, and marijuana with risk of recurrence and progression of non-muscle-invasive bladder cancer (NMIBC) and to explore use of smoking cessation interventions. Design, Setting, and Participants: The Be-Well Study is a prospective cohort study of patients with NMIBC diagnosed from 2015 to 2019 and followed-up for 26.4 months in the Kaiser Permanente Northern and Southern California integrated health care system. Eligibility criteria were age at least 21 years, first NMIBC diagnosis (stages Ta, Tis, or T1), alive, and not in hospice care. Exclusion criteria were previous diagnosis of bladder cancer or other cancer diagnoses within 1 year prior to or concurrent with NMIBC diagnosis. Data were analyzed from April 1 to October 4, 2022. Exposures: Use of cigarettes, pipes, cigars, e-cigarettes, and marijuana was reported in the baseline interview. Use of smoking cessation interventions (counseling and medications) was derived from electronic health records. Main Outcomes and Measures: Hazard ratios (HRs) and 95% CIs of recurrence and progression of bladder cancer were estimated by multivariable Cox proportional hazards regression. Results: A total of 1472 patients (mean [SD] age at diagnosis, 70.2 [10.8%] years; 1129 [76.7%] male patients) with N...