Spectrum of underlying diseases in syncope and treatment of neurally-mediated syncope in children and adolescents over the past 30 years: A single center study

作者：Yaxi Cui, Ying Liao, Qingyou Zhang, Hui Yan, Ping Liu, Yuli Wang, Yan Sun, Wenrui Xu, Xueqin Liu, Junbao Du, Hongfang Jin · 发表于：Frontiers in Cardiovascular Medicine · 年份：2022 · DOI：10.3389/fcvm.2022.1017505 · 被引用次数：10 · 研究领域：Cardiovascular Syncope and Autonomic Disorders、Neurological Disorders and Treatments、Takotsubo Cardiomyopathy and Associated Phenomena

Background Syncope is the primary cause of transient loss of consciousness, which causes severe physical and mental burdens to children and adolescents. Objective The study was designed to analyze the spectrum of underlying diseases of syncope and treatment options for neurally-mediated syncope (NMS) in Chinese children and adolescents. Methods Medical records including history, physical examination, blood biochemistry, standing test, head-up tilt (HUTT), sitting-up test, electroencephalogram (EEG), electrocardiogram (ECG), and echocardiography were retrospectively studied in children and adolescents admitted to the National Pediatric Syncope Center, Department of Pediatrics, Peking University First Hospital between 1992 and 2021. All the data were collected from the Beijing Kaihua Medical Management System (Kaihua, Beijing, China). Children who met the syncope diagnostic criteria were enrolled in the study. The spectrum of the underlying diseases of syncope in children and adolescents and the treatment options of NMS were analyzed. Results A total of 1,947 children and adolescents with syncope were admitted, including 869 males (44.63%) and 1,078 females (55.37%) aged 1–18 years, with an average age of 11.1 ± 3.1 years. The number of children and adolescents with syncope displayed a gradually increasing trend between 1992 and 2021 except after 2020. NMS proportion increased, and the proportion of unexplained syncope decreased (χ 2 = 128.839, P < 0.01). The treatment o...