Global, regional, and national burden and attributable risk factors of neurological disorders: The Global Burden of Disease study 1990–2019

作者：Chenyu Ding, Yuying Wu, Xiaoyong Chen, Yue Chen, Zanyi Wu, Zhangya Lin, Dezhi Kang, Wenhua Fang, Fa Chen · 发表于：Frontiers in Public Health · 年份：2022 · DOI：10.3389/fpubh.2022.952161 · 被引用次数：313 · 研究领域：Acute Ischemic Stroke Management、Neurology and Historical Studies、Dementia and Cognitive Impairment Research

Background: Neurological disorders are a major and increasing global health challenge, which accounts for a substantial portion of the disease burden worldwide. The aim of this systematic analysis is to present the most comprehensive and up-to-date estimates of disease burden, epidemiological trends, and attributable risk factors of neurological disorders at global, regional, and national levels. Methods: We extracted data of 18 neurological disorders from the Global Burden of Disease 2019 study database. The burden of neurological disorders was measured using the incidence, prevalence, mortality, and disability-adjusted life years (DALYs), and further described according to age, sex, year, geographical location and socio-demographic Index (SDI). All estimates were presented with corresponding 95% uncertainty intervals (UIs). Findings: Globally, in 2019, there were nearly 10 million deaths and 349 million DALYs due to neurological disorders. Among the 18 neurological disorders, stroke was the biggest contributor to DALYs (143232.18 [95%UI 133095.81-153241.82] in thousands) and deaths (6552.72 [95%UI 5995.20-7015.14] in thousands), followed by neonatal encephalopathy due to birth asphyxia and trauma. From 1990 to 2019, the DALYs of neurological diseases belonging to the communicable, maternal, neonatal and nutritional categories showed a sharp decrease, while Alzheimer's disease and other dementias and Parkinson's disease showed a large increase. Neurological disorders exhibit...