The Flavonoid Components of Scutellaria baicalensis: BiopharmaceuticalProperties and their Improvement using Nanoformulation Techniques

作者：Jiaxin Pi, Jilin Wang, Xiaojiao Feng, Ziwei Li, Yiting Liu, Wenzhuo Yang, Tingen Zhang, Pan Guo, Zhidong Liu, Dongli Qi · 发表于：Current Topics in Medicinal Chemistry · 年份：2022 · DOI：10.2174/1568026623666221128144258 · 被引用次数：47 · 研究领域：Flavonoids in Medical Research、Natural product bioactivities and synthesis、Phytochemistry and Biological Activities

Scutellaria baicalensis georgi, known as "Huangqin" in its dried root form, is a herb widely used in traditional Chinese medicine for "clearing away heat, removing dampness, purging fire and detoxification". Baicalin, baicalein, wogonin, and wogonoside are the main flavonoid compounds found in Scutellaria baicalensis. Scutellaria baicalensis flavonoid components have the potential to prevent and treat a host of diseases. The components of S. baicalensis have limited clinical application due to their low water solubility, poor permeability, and microbial transformation in vivo. Nanopharmaceutical techniques can improve their biopharmaceutical properties, enhance their absorption in vivo, and improve their bioavailability. However, due to the limited number of clinical trials, doubts remain about their toxicity and improvements in human absorption as a result of nanoformulations. This review summarizes the latest and most comprehensive information regarding the absorption, distribution, metabolism, and excretion of the Scutellaria baicalensis components in vivo. We examined the main advantages of nanodrug delivery systems and collected detailed information on the nanosystem delivery of the Scutellaria baicalensis components, including nanosuspensions and various lipid-based nanosystems. Lipid-based systems including liposomes, solid lipid nanoparticles, nanoemulsions, and self-micro emulsifying drug delivery systems are introduced in detail. In addition, we make recommendations...