Impact of Dialysis Dependence on Survival for Multiple Myeloma Patients with Renal Impairment: A Multicenter Retrospective Study in China

作者：Yuan Jian, Huixing Zhou, Weiwei Xie, Yuan Ren, Zhiyao Zhang, Guangzhong Yang, Chuanying Geng, Jing Jia, Wen-Ming Chen, Li J, Wenrong Huang, Xinan Cen, Wen Gao · 发表于：Blood · 年份：2022 · DOI：10.1182/blood-2022-159950 · 被引用次数：1 · 研究领域：Multiple Myeloma Research and Treatments、Amyloidosis: Diagnosis, Treatment, Outcomes、Drug Transport and Resistance Mechanisms

Background: Renal impairment is a very common complication of multiple myeloma (MM) with a negative impact on survival. About 20-40% of de novo multiple myeloma suffer from renal impairment, while 10% require dialysis support. In the traditional agent era, the prognosis for dialysis dependence was very poor. But in the novel agent era, the data for survival of multiple myeloma with dialysis dependence are quite limited. Methods: In this multicenter study, we retrospectively analyzed 337 MM patients with renal impairment at diagnosis between April 2004 to Jan 2020 from three hospitals in China. Renal impairment was defined as estimated glomerular filtration rate (eGFR) < 40ml/min and/or serum creatinine ≤ 177μmol/L. RI caused by other reasons than tubular nephropathy was excluded. Dialysis dependence was defined as dialysis support started at front-line treatment or at relapse without recovering. Results: Of all 337 patients, 54 patients were in the dialysis dependence group. Of patients without dialysis dependence, 42 were in the dialysis independent group, and 241 were in the without dialysis group. The baseline characteristics of the three groups are summarized in Table 1. There were significant differences in LDH and renal function among the three groups respectively and the dialysis dependence group had the highest value of both LDH and serum creatine. In cytogenetics, t(11;14) were more prevalent for dialysis dependence group compared with other two groups (24.1% vs. 11....