Radiological biomarkers of idiopathic normal pressure hydrocephalus: new approaches for detecting concomitant Alzheimer's disease and predicting prognosis

作者：Hanlin Cai, Yinxi Zou, Hui Gao, Keru Huang, Yu Liu, Yuting Cheng, Yi Liu, Liangxue Zhou, Dong Zhou, Qin Chen · 发表于：Psychoradiology · 年份：2022 · DOI：10.1093/psyrad/kkac019 · 被引用次数：3 · 研究领域：Cerebrospinal fluid and hydrocephalus、Fetal and Pediatric Neurological Disorders、Traumatic Brain Injury and Neurovascular Disturbances

Abstract Idiopathic normal pressure hydrocephalus (iNPH) is a clinical syndrome characterized by cognitive decline, gait disturbance, and urinary incontinence. As iNPH often occurs in elderly individuals prone to many types of comorbidity, a differential diagnosis with other neurodegenerative diseases is crucial, especially Alzheimer's disease (AD). A growing body of published work provides evidence of radiological methods, including multimodal magnetic resonance imaging and positron emission tomography, which may help noninvasively differentiate iNPH from AD or reveal concurrent AD pathology in vivo. Imaging methods detecting morphological changes, white matter microstructural changes, cerebrospinal fluid circulation, and molecular imaging have been widely applied in iNPH patients. Here, we review radiological biomarkers using different methods in evaluating iNPH pathophysiology and differentiating or detecting concomitant AD, to noninvasively predict the possible outcome postshunt and select candidates for shunt surgery.