Integrated porous polyetheretherketone implants for treating skull defect

作者：Mingguang Zhang, Mei‐li Qi, Kunshan Yuan, Hanjie Liu, Jinping Ren, Aihua Liu, Shengkun Yao, Xiangrui Guo, Xiushan Li, Haijun Zhang · 发表于：Journal of Materials Research and Technology · 年份：2022 · DOI：10.1016/j.jmrt.2022.11.122 · 被引用次数：20 · 研究领域：Head and Neck Surgical Oncology、Traumatic Brain Injury and Neurovascular Disturbances、Spinal Fractures and Fixation Techniques

Skull defect is a common clinical disease, and the corresponding treatment is still a grand challenge. No artificial product can perfectly integrate with human skull and match the skull defect during growth. Herein, we report a porous polyetheretherketone (PEEK) implant with the microstructures almost identical to natural bones for repairing skull defect. Compared to non-porous PEEK controls, the porous PEEK implants efficiently promote cell adhesion, regenerate skull tissues, and finally achieve perfect healing with surrounding tissues within 6 months. This work suggests the important potential of integrated porous PEEK implants for treating skull defect in clinic, especially for children with rapidly growing skulls.