Enhanced Cherenkov imaging for real‐time beam visualization by applying a novel carbon quantum dot sheeting in radiotherapy

作者：Xing Di, Changran Geng, Chang Guo, Yufen Shang, Hongtao Fu, Haonan Han, Xiaobin Tang · 发表于：Medical Physics · 年份：2022 · DOI：10.1002/mp.16121 · 被引用次数：6 · 研究领域：Carbon and Quantum Dots Applications、Biofield Effects and Biophysics、Photodynamic Therapy Research Studies

BACKGROUND: Cherenkov imaging can be used to visualize the placement of the beam directly on the patient's surface tissue and evaluate the accuracy of treatment planning. However, Cherenkov emission intensity is lower than ambient light. At present, time gating is the only way to realize Cherenkov imaging with ambient light. PURPOSE: This study proposes preparing a novel carbon quantum dot (cQD) sheeting to adjust the wavelength of Cherenkov emission to obtain the optimal wavelength meeting the sensitive detection region of the camera, meanwhile the total optical signal is also increased. By combining a specific filter, this approach might help in using lower-cost camera systems without intensifier-coupled to accomplish in vivo monitoring of the surface beam profile on patients with ambient light. METHODS: The cQD sheetings were prepared by spin coating and UV curing with different concentrations. All experiments were performed on the Varian VitalBeam system and optical emission was captured using an electron multiplying charge-coupled device (EMCCD) camera. To quantify the optical characteristics and certify the improvement of light intensity as well as signal-to-noise ratio (SNR) of cQD sheeting, the first part of the study was carried out on solid water with 6 and 10 MV photon beams. The second part was carried out on an anthropomorphic phantom to explore the applicability of sheeting when using different radiotherapy materials and the imaging effect of sheeting with the i...