A Sweet Warning: Mucin-Type O-Glycans in Cancer

作者：Yuhan Zhang, Lingbo Sun, Changda Lei, Changda Lei, Jiaqi Han, Jiaqi Han, Jing Zhang · 发表于：Cells · 年份：2022 · DOI：10.3390/cells11223666 · 被引用次数：59 · 研究领域：Glycosylation and Glycoproteins Research、Carbohydrate Chemistry and Synthesis、Galectins and Cancer Biology

Glycosylation is a common post-translational modification process of proteins. Mucin-type O-glycosylation is an O-glycosylation that starts from protein serine/threonine residues. Normally, it is involved in the normal development and differentiation of cells and tissues, abnormal glycosylation can lead to a variety of diseases, especially cancer. This paper reviews the normal biosynthesis of mucin-type O-glycans and their role in the maintenance of body health, followed by the mechanisms of abnormal mucin-type O-glycosylation in the development of diseases, especially tumors, including the effects of Tn, STn, T antigen, and different glycosyltransferases, with special emphasis on their role in the development of gastric cancer. Finally, tumor immunotherapy targeting mucin-type O-glycans was discussed.