Efficacy and Safety of Hyaluronic Acid Intra‐articular Injection after Arthroscopic Knee Surgery: A Systematic Review and Meta‐analysis

作者：Beini Mao, Yunlong Pan, Zhong Zhang, Zeping Yu, Jian Li, Weili Fu · 发表于：Orthopaedic Surgery · 年份：2022 · DOI：10.1111/os.13602 · 被引用次数：14 · 研究领域：Osteoarthritis Treatment and Mechanisms、Total Knee Arthroplasty Outcomes、Proteoglycans and glycosaminoglycans research

OBJECTIVE: Hyaluronic acid (HA) intra-articular injection after arthroscopic knee surgery has been widely applied but its efficacy and safety remain controversial. The aim of this systematic review is to analyze the efficacy and safety of HA intra-articular injection after arthroscopic knee surgery, and to compare the efficacy of HA with different molecular weights. METHODS: We conducted a systematic literature search in PubMed, Embase, Google scholar and the Cochrane library from inception to 16 September 2022 for English-written articles, in order to identify randomized controlled trials that evaluated the clinical efficacy and/or safety of HA intra-articular injection after arthroscopic knee surgery. Then we meta-analyzed the outcomes of patients given intra-articular HA injections postoperatively and control patients. We also evaluated the influence of HA with different molecular weights. In every calculation, sensitive analysis was performed. The visual analogue scale (VAS) for pain, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and adverse events were selected as the primary outcome measurements, while Lysholm, International Knee Documentation Committee (IKDC) and Tegner score were selected as the secondary outcome measurements. Publication bias of every outcome was evaluated using egger test. RESULTS: Fifteen studies involving 951 knees were included and 12 of them were used to performed the meta-analysis. The results showed no significant diff...