Human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks: a global case series

作者：John Thornhill, Romain Palich, Jade Ghosn, Sharon Walmsley, Davide Moschese, Claudia P. Cortés, Rafael Mello Galliez, Amy B. Garlin, Silvia Nozza, Oriol Mitja, Asa Radix, José Luís Blanco, Brenda Crabtree‐Ramírez, Melanie Thompson, Lothar Wiese, Hubert Schulbin, Ariela Levcovich, Marco Falcone, Anna Lucchini, Elena Sendagorta, Carl-Johan Treutiger, Ruth Byrne, Katherine Coyne, Eric A. Meyerowitz, Anna Grahn, Ann‐Brit Eg Hansen, Valérie Pourcher, Michelle DellaPiazza, Rachel Lee, Marcel Stoeckle, Aniruddha Hazra, Vanessa Apea, Emma Rubenstein, Joyce Jones, Aimee Wilkin, Anuradha Ganesan, Andrés F. Henao‐Martínez, Eric J. Chow, Boghuma K Titanji, Jason Zucker, Dimie Ogoina, Chloe Orkin · 发表于：The Lancet · 年份：2022 · DOI：10.1016/s0140-6736(22)02187-0 · 被引用次数：154 · 研究领域：Poxvirus research and outbreaks、Cervical Cancer and HPV Research、Herpesvirus Infections and Treatments

BACKGROUND: Between May and November, 2022, global outbreaks of human monkeypox virus infection have been reported in more than 78 000 people worldwide, predominantly in men who have sex with men. We describe the epidemiological and clinical characteristics of monkeypox virus infection in cisgender (cis) and transgender (trans) women and non-binary individuals assigned female sex at birth to improve identification and understanding of risk factors. METHODS: International collaborators in geographical locations with high numbers of diagnoses of monkeypox virus infection were approached and invited to contribute data on women and non-binary individuals with confirmed monkeypox virus infection. Contributing centres completed deidentified structured case-report spreadsheets, adapted and developed by participating clinicians, to include variables of interest relevant to women and non-binary individuals assigned female at birth. We describe the epidemiology and clinical course observed in the reported infections. FINDINGS: Collaborators reported data for a total of 136 individuals with monkeypox virus infection who presented between May 11 and Oct 4, 2022, across 15 countries. Overall median age was 34 years (IQR 28-40; range 19-84). The cohort comprised 62 trans women, 69 cis women, and five non-binary individuals (who were, because of small numbers, grouped with cis women to form a category of people assigned female at birth for the purpose of comparison). 121 (89%) of 136 indivi...